FAP is caused by a mutation in the adenomatous polyposis coli (APC) gene coding for APC protein, which acts as a tumor suppressor and keeps cells from growing too fast or in an uncontrolled way.
It is characterized by polyps developing as early as the teens.1-3
80% OF CRC PATIENTS 80% OF CRC PATIENTS
have an APC mutation.
Erythromycin treatment
shown to reduce both
the amount and size
of polyps
Response to ZKN-013
shown in tumor grafts
ex-vivo from patients
with FAP derived CRC
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December 2023
